منابع مشابه
A New Pillar in Pilus Assembly
Pilus assembly in bacteria typically occurs by one of four pathways. In the study by Xu et al., the structures of 20 pilin subunits of human oral and gut Bacteroidales are elucidated, revealing a new pilin superfamily, assembled into pili by a distinct fifth pathway.
متن کاملChaperone-assisted pilus assembly and bacterial attachment.
Bacterial pili assembled by the chaperone-usher pathway can mediate microbial attachment, an early step in the establishment of an infection, by binding specifically to sugars present in host tissues. Recent work has begun to reveal the structural basis both of chaperone function in the biogenesis of these pili and of bacterial attachment.
متن کاملLifting the lid on pilus assembly
A combination of computer simulations, evolutionary analysis and graph theory has provided new insights into the assembly of pili on the surface of bacteria.
متن کاملInteraction of the cyclic-di-GMP binding protein FimX and the Type 4 pilus assembly ATPase promotes pilus assembly
Type IVa pili (T4P) are bacterial surface structures that enable motility, adhesion, biofilm formation and virulence. T4P are assembled by nanomachines that span the bacterial cell envelope. Cycles of T4P assembly and retraction, powered by the ATPases PilB and PilT, allow bacteria to attach to and pull themselves along surfaces, so-called "twitching motility". These opposing ATPase activities ...
متن کاملType IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions.
Type IV pili (T4P) are long, thin, flexible filaments on bacteria that undergo assembly-disassembly from inner membrane pilin subunits and exhibit astonishing multifunctionality. Neisseria gonorrhoeae (gonococcal or GC) T4P are prototypic virulence factors and immune targets for increasingly antibiotic-resistant human pathogens, yet detailed structures are unavailable for any T4P. Here, we dete...
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ژورنال
عنوان ژورنال: Cell
سال: 2016
ISSN: 0092-8674
DOI: 10.1016/j.cell.2016.04.024